Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male <i>Mecp2</i> mutant mice

Abstract

CBDV administration exerts an enduring rescue of memory deficits in <i>Mecp2</i> mutant mice, an effect that is associated with the normalization of BDNF, IGF-1 and rpS6 phosphorylation levels as well as CB1 and CB2 receptor expression. CBDV delays neurological defects but this effect is only transient.