Spectrophotometric determination of α-hydroxytropolone pKa values: A structure-acidity relationship study

Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs

Ruth Allen, Karl Box, John Comer et al. · Journal of Pharmaceutical and Biomedical Analysis · 1998 · 176 citations

Natural Sciences, Chemistry, Pharmaceutical Analysis +13

Ring Structure and Aromatic Substituent Effects on the p<i>K</i>_aof the Benzoxaborole Pharmacophore

John W. Tomsho, Arnab Pal, Dennis G. Hall et al. · ACS Medicinal Chemistry Letters · 2011 · 140 citations

Pharmacy, Chemistry, Medicinal Chemistry +15

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Suhman Chung, D.M. Himmel, Jian‐kang Jiang et al. · Journal of Medicinal Chemistry · 2011 · 79 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Rapid Determination of Ionization Constants (p<i>K</i>_a) by UV Spectroscopy Using 96-Well Microtiter Plates

Carlos Martinez, Christophe Dardonville · ACS Medicinal Chemistry Letters · 2012 · 76 citations

Natural Sciences, Biochemistry, Chemistry +12

An Oxidopyrylium Cyclization/Ring-Opening Route to Polysubstituted α-Hydroxytropolones

Christine Meck, Noushad Mohd, Ryan P. Murelli · Organic Letters · 2012 · 65 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7