Concepedia

Pka Determination

pKa Determination is a physicochemical analytical procedure that quantifies the acid dissociation constant(s) of an ionizable drug substance under defined experimental conditions, thereby characterizing its ionization behavior relevant to solubility, stability, and formulation design in preformulation studies.

5.6K

Publications

267.3K

Citations

13.9K

Authors

2.5K

Institutions

Publications per year

2017–2026

474

Variants

Pka Measurement

Parents

Children

Publications

5.6K

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical p<i>K</i><sub>a</sub>Predictions

Mats H. M. Olsson, Chresten R. Søndergaard, Michał Rostkowski et al. · Journal of Chemical Theory and Computation · 2011 · 4.5K citations

, , +14

[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

C. Nick Pace · Methods in enzymology on CD-ROM/Methods in enzymology · 1986 · 2.3K citations

, , +3

Very fast empirical prediction and rationalization of protein pK<sub>a</sub> values

Hui Li, Andrew D. Robertson, Jan H. Jensen · Proteins Structure Function and Bioinformatics · 2005 · 2.1K citations

, , +13

H++: a server for estimating pKas and adding missing hydrogens to macromolecules

John Gordon, Joseph B. Myers, T. Folta et al. · Nucleic Acids Research · 2005 · 1.8K citations · Full text

, , +17

THE DETERMINATION OF INORGANIC PHOSPHATE IN THE PRESENCE OF LABILE PHOSPHATE ESTERS

Oliver H. Lowry, Jeanne A. Lopez · Journal of Biological Chemistry · 1946 · 1.6K citations · Full text

, , +7

1–5 of 5.6K

Authors

13.9K

  1. MR
    Martı́ Rosés

    Universitat de Barcelona, Spain

    36 publications · 2.3K citations

    25

    h-index

  2. SS
    Silvio Sammartano

    University of Messina, Italy

    43 publications · 1.6K citations

    24

    h-index

  3. IL
    Ivo Leito

    University of Tartu, Estonia

    25 publications · 2.5K citations

    23

    h-index

  4. EB
    Elisabeth Bosch

    Universitat de Barcelona, Spain

    34 publications · 2.4K citations

    23

    h-index

  5. CR
    Clara Ràfols

    Universitat de Barcelona, Spain

    25 publications · 1.3K citations

    20

    h-index

1–5 of 13.9K

Institutions

2.5K

  1. Centre National de la Recherche Scientifique

    Paris, France

    38 h-index

    258 publications

    15.6K citations

  2. Universitat de Barcelona

    Barcelona, Spain

    36 h-index

    259 publications

    16.5K citations

  3. University of Tartu

    Tartu, Estonia

    25 h-index

    132 publications

    13K citations

  4. University of Messina

    Messina, Italy

    24 h-index

    154 publications

    4.5K citations

  5. Oak Ridge National Laboratory

    Oak Ridge, United States

    22 h-index

    78 publications

    7K citations

  6. East Sussex County Council

    Lewes, United Kingdom

    18 h-index

    33 publications

    4.2K citations

  7. Kyushu University

    Fukuoka, Japan

    18 h-index

    83 publications

    3.2K citations

  8. Chinese Academy of Sciences

    Beijing, China

    18 h-index

    108 publications

    5.2K citations

1–8 of 2.5K

Venues

  1. Journal of the American Chemical Society

    JACS · 508 publications · 26.1K citations

    79

    h-index

  2. Analytical Chemistry

    162 publications · 6.9K citations

    46

    h-index

  3. The Journal of Physical Chemistry

    153 publications · 8.2K citations

    44

    h-index

  4. Biochemistry

    64 publications · 4.3K citations

    42

    h-index

  5. The Journal of Organic Chemistry

    JOC · 117 publications · 5.7K citations

    40

    h-index

1–5