Nucleic Acids Research · 2019 · 1.4K citations · 29 references
Life SciencesBiochemistryBioinformaticsComputational BiologyProteomicsSequence AnalysisProtein Database SearchProtein Sequence AnalysisSequence Similarity SearchDatabase SearchingPeptide Database SearchPeptide Sequence SearchProtein Identification AlgorithmsProtein Reference DatabasesProtein Sequence Database ConstructionWeb Server Architecture
The PSIPRED Workbench has provided a web server with diverse predictive methods to the bioscience community for two decades. The authors aim to update the PSIPRED Workbench to sustain its service for another 20 years, prioritizing faster analyses amid expanding protein sequence databases. The upgrade includes new software, upgraded hardware infrastructure, enhanced web services and site, and refreshed key predictive algorithms.
Abstract The PSIPRED Workbench is a web server offering a range of predictive methods to the bioscience community for 20 years. Here, we present the work we have completed to update the PSIPRED Protein Analysis Workbench and make it ready for the next 20 years. The main focus of our recent website upgrade work has been the acceleration of analyses in the face of increasing protein sequence database size. We additionally discuss any new software, the new hardware infrastructure, our webservices and web site. Lastly we survey updates to some of the key predictive algorithms available through our website.
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Helen M. Berman · Nucleic Acids Research · 2000 · 39.8K citations
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Lawrence A. Kelley, Stefans Mezulis, Christopher M. Yates et al. · Nature Protocols · 2015 · 10.2K citations · Full text
HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment
Michael Remmert, A. Biegert, Andreas Hauser et al. · Nature Methods · 2011 · 2.5K citations · Full text