PKM2 Involved in Neuronal Apoptosis on Hypoxic-ischemic Encephalopathy in Neonatal Rats

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

Medicine, Cancer Biology, Oncology +16

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

John E. Rice, Robert C. Vannucci, J. B. Brierley · Annals of Neurology · 1981 · 2.1K citations

Life Sciences, Neurobiology, Neuroscience +14

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

Xueliang Gao, Haizhen Wang, Jenny Yang et al. · Molecular Cell · 2012 · 767 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Qian Sun, Xinxin Chen, Jianhui Ma et al. · Proceedings of the National Academy of Sciences · 2011 · 576 citations · Full text

Life Sciences, Biochemistry, Oncology +17

Delayed (“Secondary”) Cerebral Energy Failure after Acute Hypoxia-Ischemia in the Newborn Piglet: Continuous 48-Hour Studies by Phosphorus Magnetic Resonance Spectroscopy

Ann Lorek, Yukito Takei, Ernest B. Cady et al. · Pediatric Research · 1994 · 559 citations · Full text

Life Sciences, Neuroscience, Physiology +16