Insulin/IGF1 signalling mediates the effects of β₂‐adrenergic agonist on muscle proteostasis and growth

Abstract

NS/IGF1 signalling is necessary for the anti-proteolytic and hypertrophic effects of in vivo β₂ -adrenergic stimulation and appears to mediate FOR-induced enhancement of protein synthesis. INS/IGF1 signalling only partially contributes to gain in strength and does not mediate fibre type transition induced by FOR.