Rifampicin effect on intracellular and plasma pharmacokinetics of tenofovir alafenamide

Abstract

Following tenofovir alafenamide/emtricitabine administration with rifampicin, intracellular tenofovir-DP concentrations were still 4.21-fold higher than those achieved by tenofovir disoproxil fumarate, supporting further study during HIV/TB co-infection.