Concepedia

Rifampin Interactions

Rifampin Interactions is a pharmacological construct that denotes the clinically significant alterations in the pharmacokinetics and pharmacodynamics of co-administered drugs—particularly immunosuppressive agents—arising from rifampin’s potent induction of hepatic cytochrome P450 enzymes and drug transporters, which distinguishes it from other drug interaction mechanisms by its predominant impact on metabolic clearance in transplant recipients.

148

Publications

7.7K

Citations

804

Authors

291

Institutions

Publications per year

2017–2026

28

Parents

Publications

148

Tuberculosis in Solid‐Organ Transplant Recipients: Consensus Statement of the Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology

José María Aguado, Julián Torre‐Cisneros, Jesús Fortün et al. · Clinical Infectious Diseases · 2009 · 256 citations

, , +17

Rifampin drastically reduces plasma concentrations and effects of oral midazolam

Janne T. Backman, Klaus T. Olkkola, Pertti J. Neuvonen · Clinical Pharmacology & Therapeutics · 1996 · 242 citations

, , +13

Update on Rifampin Drug Interactions

Anne M. Baciewicz · Archives of Internal Medicine · 1987 · 197 citations

, , +17

Pharmacokinetics of Adjusted-Dose Lopinavir-Ritonavir Combined with Rifampin in Healthy Volunteers

C. J. L. la Porte, E. P. H. Colbers, Richard Bertz et al. · Antimicrobial Agents and Chemotherapy · 2004 · 185 citations · Full text

, , +14

The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolism.

N Holtbecker, Martin F. Fromm, H. Kroemer et al. · Drug Metabolism and Disposition · 1996 · 179 citations

, , +17

1–5 of 148

Authors

804

  1. CA
    Charles A. Peloquin

    University of Florida, United States

    6 publications · 388 citations

    6

    h-index

  2. TH
    Timothy H. Self

    University of Tennessee Health Science Center, United States

    5 publications · 135 citations

    5

    h-index

  3. PJ
    Pertti J. Neuvonen

    University of Helsinki, Finland

    4 publications · 496 citations

    4

    h-index

  4. KT
    Klaus T. Olkkola

    University of Helsinki, Finland

    3 publications · 449 citations

    3

    h-index

  5. CF
    Charles Flexner

    Johns Hopkins University, United States

    3 publications · 189 citations

    3

    h-index

1–5 of 804

Institutions

291

  1. Johns Hopkins University

    Baltimore, United States

    5 h-index

    19 publications

    1.5K citations

  2. University of Tennessee Health Science Center

    Memphis, United States

    5 h-index

    8 publications

    198 citations

  3. Pfizer (United States)

    New York, United States

    5 h-index

    25 publications

    1.5K citations

  4. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    5 h-index

    46 publications

    2.9K citations

  5. University of Helsinki

    Helsinki, Finland

    4 h-index

    14 publications

    1.6K citations

  6. University of Cape Town

    Rondebosch, South Africa

    4 h-index

    8 publications

    217 citations

  7. University of Colorado Denver

    Denver, United States

    4 h-index

    4 publications

    256 citations

  8. Johns Hopkins Medicine

    Baltimore, United States

    4 h-index

    14 publications

    1.1K citations

1–8 of 291

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 20 publications · 1.3K citations

    18

    h-index

  2. Clinical Pharmacology & Therapeutics

    CPT · 17 publications · 1.4K citations

    16

    h-index

  3. The Journal of Clinical Pharmacology

    10 publications · 414 citations

    10

    h-index

  4. PubMed

    Repository · 8 publications · 270 citations

    8

    h-index

  5. Clinical Infectious Diseases

    CID · 7 publications · 656 citations

    7

    h-index

1–5