Concepedia

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

Jinhuan Wu, Yuping Chen, Guohe Geng, Lei Li, Ping Yin, Somaira Nowsheen, Yunhui Li, Chenming Wu, Jiaqi Liu, Fei Zhao,

Cancer Letters · 2019 · 68 citations · 43 references

DOI

Concepts

References

43

Chk1 is an essential kinase that is regulated by Atr and required for the G<sub>2</sub>/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

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Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

Satomi Matsuoka · 1998 · 1.3K citations

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DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

Atsushi Hirao, Young‐Yun Kong, Shuhei Matsuoka et al. · Science · 2000 · 1.3K citations

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The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Jacob Falck, Niels Mailand, Randi G. Syljuåsen et al. · Nature · 2001 · 1.1K citations

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Sheau-Yann Shieh, Katsuyuki Tamai, Yoichi Taya et al. · Genes & Development · 2000 · 955 citations · Full text

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