PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Xinyi Tu, Bo Qin, Yong Zhang, +16

Molecular Cell

Genome InstabilityMolecular BiologyCan BeRna ExosomeDna Damage Response +5

The intersection between DNA damage response and cell death pathways.

Somaira Nowsheen, Eddy S. Yang

PubMed

Dna DamageSuch StressApoptosisImmunologyCell Death Pathways +15

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Jia Yu, Bo Qin, Ann M. Moyer, +19

Journal of Clinical Investigation

Breast OncologyEngineeringCancer BiologyEpigeneticsTumor Biology +15

UFL1 promotes histone H4 ufmylation and ATM activation

Bo Qin, Jia Yu, Somaira Nowsheen, +6

Nature Communications

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Seung Baek Lee, Jung‐Jin Kim, Sang‐Ah Han, +16

Nature Cell Biology

Signal TransductionAmpk–parkin AxisSignaling PathwayCell RegulationApoptosis +8

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Tongzheng Liu, Jia Yu, Min Deng, +20

Nature Communications

Tumors induce complex DNA damage in distant proliferative tissues in vivo

Christophe E. Redon, Jennifer S. Dickey, Asako Nakamura, +7

Proceedings of the National Academy of Sciences

Dna DamageImmunologyPathologyCancer BiologyTumor Biology +19

USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

Yunhui Li, Kuntian Luo, Yujiao Yin, +7

Nature Communications

Regulation of sister chromatid cohesion by nuclear PD-L1

Jia Yu, Bo Qin, Ann M. Moyer, +8

Cell Research

GeneticsImmunologyCell DeathEpigeneticsTranscriptional Regulation +15

Synthetic Lethal Interactions between EGFR and PARP Inhibition in Human Triple Negative Breast Cancer Cells

Somaira Nowsheen, Tiffiny S. Cooper, Jennifer Stanley, +1

PLoS ONE

Breast OncologyParp InhibitionSynthetic Lethal InteractionsBrca1 InteractionMedicine +12