Publication | Open Access
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt
65
Citations
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References
2019
Year
Molecular BiologyChemical BiologyPharmaceutical ChemistryMolecular PharmacologyMedicinal ChemistryChemical InsightsBiological EvaluationCovalent-allosteric InhibitionProtein FunctionBiochemistryG Protein-coupled ReceptorDrug DevelopmentPharmacologyMolecular ModelingProtein PhosphorylationStructure-based Driven SynthesisNatural SciencesRational Drug DesignProtein Kinase AktMedicineDrug Discovery
Structure-based driven synthesis and biological evaluation provide innovative novel covalent-allosteric Akt inhibitors.
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