Concepedia

Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation

Mutsuko Minata, Alessandra Audia, Junfeng Shi, Songjian Lu, Joshua D. Bernstock, Marat S. Pavlyukov, Arvid Das, Sung-Hak Kim, Yong Jae Shin, Yeri Lee,

Cell Reports · 2019 · 219 citations · 65 references

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Concepts

Abstract

cells are highly enriched with clonogenic, tumor-initiating, and radiation-resistant properties, and silencing CD109 significantly inhibits these phenotypes. We also report a conserved regulation of YAP/TAZ pathways by CD109 that could be a therapeutic target in GBM.

References

65

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010

Quinn T. Ostrom, Haley Gittleman, P Farah et al. · Neuro-Oncology · 2013 · 12.1K citations · Full text

, , +14

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

Roel G.W. Verhaak, Katherine A. Hoadley, Elizabeth Purdom et al. · Cancer Cell · 2010 · 7.7K citations · Full text

, , +12

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Shideng Bao, Qiulian Wu, Roger E. McLendon et al. · Nature · 2006 · 6.4K citations

, , +16

Role of YAP/TAZ in mechanotransduction

Sirio Dupont, Leonardo Morsut, Mariaceleste Aragona et al. · Nature · 2011 · 5.9K citations · Full text

, , +5

A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival

Michel Lacroix, Dima Abi-Said, Daryl R. Fourney et al. · Journal of neurosurgery · 2001 · 3.1K citations

, , +17