Concepedia

IL-4-polarized BV2 microglia cells promote angiogenesis by secreting exosomes

Yan Tian, Pei Zhu, Shanshan Liu, Zheng Jin, Dong Li, Heng Zhao, Xun Sheng Zhu, Chang Shu, Dongmei Yan, Zehua Dong

Advances in Clinical and Experimental Medicine · 2019 · 98 citations · 28 references

DOIFull text

Open access

Abstract

Interleukin-4-polarized microglia cells might ameliorate the damage caused by ischemic stroke by promoting angiogenesis through the secretion of exosomes containing miRNA-26a.

References

28

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

Xiaoming Hu, Peiying Li, Yanling Guo et al. · Stroke · 2012 · 1.5K citations · Full text

Hypoxic enhancement of exosome release by breast cancer cells

Hamish W. King, Michael Michael, Jonathan Gleadle · BMC Cancer · 2012 · 1.1K citations · Full text

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

Hongqi Xin, Yi Li, Yisheng Cui et al. · Journal of Cerebral Blood Flow & Metabolism · 2013 · 953 citations · Full text

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Paulina Kucharzewska, Helena C. Christianson, Johanna E. Welch et al. · Proceedings of the National Academy of Sciences · 2013 · 925 citations · Full text

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Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

Nadine Jetten, Sanne Verbruggen, Marion J. Gijbels et al. · Angiogenesis · 2013 · 832 citations

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