Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

F. William Studier, Barbara A. Moffatt · Journal of Molecular Biology · 1986 · 6.4K citations

Selective High-level Expression, Natural Sciences, Phage Biology +8

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Gérard I. Evan, George K. Lewis, Gary Ramsay et al. · Molecular and Cellular Biology · 1985 · 2.4K citations

Immunocytochemical Technique, Immunology, Pathology +16

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

Abraham M. de Vos, Mark Ultsch, Anthony A. Kossiakoff · Science · 1992 · 2.2K citations

Crystal Structure, Human Growth, Extracellular Domain +17

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Tetsuya Taga, Masahiko Hibi, Yuuichi Hirata et al. · Cell · 1989 · 1.4K citations

Inflammation, Cytokine, Signal Transduction +13

Molecular cloning and expression of an IL-6 signal transducer, gp130

Masahiko Hibi, Masaaki Murakami, Mikiyoshi Saito et al. · Cell · 1990 · 1.3K citations

Molecular Physiology, Signal Transduction, Natural Sciences +7