Sergio Serafini

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

Philip Jones, Sergio Altamura, Raffaele De Francesco et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 99 citations · Full text

Histone Modifications, Chromatin, Biochemistry +9

Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence

Licia Tomei, Alessandra Vitelli, Raffaele De Francesco et al. · Journal of General Virology · 2000 · 77 citations

Viral Replication, Hepatitis C Virus, Molecular Biology +17

A series of novel, potent, and selective histone deacetylase inhibitors

Philip Jones, Sergio Altamura, Prasun K. Chakravarty et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 66 citations · Full text

Histone Modifications, Chromatin, Medicinal Chemistry +8

Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.

Carlo Toniatti, Andrea Cabibbo, E. Sporena et al. · The EMBO Journal · 1996 · 62 citations · Full text

Inflammation, Cytokine, Molecular Immunology +7

Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy

Jesus M. Ontoria, Sergio Altamura, Annalise Di Marco et al. · Journal of Medicinal Chemistry · 2009 · 61 citations · Full text