Concepedia

Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancer

Yizhou Yao, Xiaoqin Yang, Liang Sun, Shishuo Sun, Xiaoheng Huang, Diyuan Zhou, Tingting Li, Wei Zhang, Nada A. Abumrad, Xinguo Zhu,

EBioMedicine · 2019 · 62 citations · 37 references

DOIFull text

Open access

Abstract

Our results demonstrate that FA2H plays an important role in regulating Hh signaling and gastric tumor growth and suggest that (R)-2-OHFAs could be effective as nontoxic wide-spectrum drugs to promote chemosensitivity. FUND: Grants of NSF, NIH, and PAPD.

References

37

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie, Belinda Phipson, Di Wu et al. · Nucleic Acids Research · 2015 · 40.9K citations · Full text

, , +19

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Gordon K. Smyth · Statistical Applications in Genetics and Molecular Biology · 2004 · 11.9K citations

, , +21

affy—analysis of <i>Affymetrix GeneChip</i> data at the probe level

Laurent Gautier, Leslie Cope, Benjamin M. Bolstad et al. · Bioinformatics · 2004 · 5.3K citations · Full text

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

Răzvan Cristescu, Jeeyun Lee, Michael Nebozhyn et al. · Nature Medicine · 2015 · 2.2K citations

, , +10

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Chen‐Song Zhang, Simon A. Hawley, Yue Zong et al. · Nature · 2017 · 693 citations · Full text

, , +1