Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck

Abstract

Combinatorial treatment with adavosertib and alisertib leads to synergistic antitumor effects in <i>in vitro</i> and <i>in vivo</i> HNSCC models. These findings suggest a novel rational combination, providing a promising therapeutic avenue for <i>TP53-</i>mutated cancers.