Macrophage fatty acid oxidation inhibits atherosclerosis progression

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.3K citations

Inflammation, Mitochondrial Function, Cell Death +7

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.8K citations · Full text

Inflammation, Signal Transduction, Oxysterol +12

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Andrew Plump, Jonathan D. Smith, Tony Hayek et al. · Cell · 1992 · 2.2K citations

Metabolic Syndrome, Lipid Disorder, Oxysterol +12

Conditional gene targeting in macrophages and granulocytes using LysMcre mice

Björn E. Clausen, Christoph Burkhardt, Walter Reith et al. · Transgenic Research · 1999 · 2.1K citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

Peter Tontonoz, László Nagy, Jacqueline G. Alvarez et al. · Cell · 1998 · 1.8K citations · Full text

Inflammation, Oxysterol, Lipid Peroxidation +8