A dual-inhibitor system for the effective antifibrillation of Aβ40 peptides by biodegradable EGCG–Fe(<scp>iii</scp>)/PVP nanoparticles

Abstract

, EGCG and PVP. The obtained EFPP NPs exhibited effective influence on the inhibition of Aβ40 fibrillation and disaggregation of existing Aβ40 fibrils. The inhibitory effect was mainly derived from the synergistic effect of the weak hydrophobicity from PVP and antioxidant activity of EGCG. With the advantages of easy synthesis, high stability in simulated body fluid, high performance towards the antifibrillation of Aβ40 and biodegradability, it is reasonable to consider that the as-prepared EFPP NPs have good application prospects in the treatment of AD.