A novel cereblon modulator for targeted protein degradation

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

Kathleen M. Sakamoto, Kyung B. Kim, Akiko Kumagai et al. · Proceedings of the National Academy of Sciences · 2001 · 2.3K citations · Full text

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Jan Krönke, Namrata D. Udeshi, Anupama Narla et al. · Science · 2013 · 1.8K citations · Full text

Hematological Malignancy, Autoimmune Disease, Mixed-phenotype Acute Leukemia +15

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

Gang Lu, Richard E. Middleton, Huahang Sun et al. · Science · 2013 · 1.5K citations · Full text

Hematological Malignancy, Cereblon-dependent Destruction, Developmental Biology +15

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd, Andrea Testa, Xavier Lucas et al. · Nature Chemical Biology · 2017 · 1.1K citations · Full text

Protein Chemistry, Biochemistry, Protac Cooperative Recognition +10

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

Jing Lü, Yimin Qian, Martha Altieri et al. · Chemistry & Biology · 2015 · 1.1K citations · Full text

Natural Sciences, Molecular Biology, Dna Replication +3