Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

Federica Sallusto, Marina Cella, Carlo Danieli et al. · The Journal of Experimental Medicine · 1995 · 2.5K citations · Full text

Bacterial Products, Immunology, Immune Regulation +22

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi et al. · Nature Immunology · 2002 · 2.5K citations

Inflammation, Immune Cells, Medicine +14

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

Fiona Harding, James G. McArthur, Jane A. Gross et al. · Nature · 1992 · 1.5K citations

Autoimmune Disease, T-cell Clones, Immunology +10

Structure-based programming of lymph-node targeting in molecular vaccines

Haipeng Liu, Kelly D. Moynihan, Yiran Zheng et al. · Nature · 2014 · 923 citations · Full text

Vaccination, Medicine, Vaccine Target +7

Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation

Sven Burgdorf, Andreas Kautz, Volker Böhnert et al. · Science · 2007 · 601 citations

T-regulatory Cell, Immunology, Immunodominance +18