Integrating Genomics into Healthcare: A Global Responsibility

TLDR

Genomic sequencing is rapidly entering clinical practice, supported by over US$4 billion in government investment across at least 14 countries, and national initiatives are driving transformative change while addressing implementation barriers and collecting evidence for broader adoption. The authors review the diversity of approaches and progress of national genomic‑medicine initiatives in the UK, France, Australia, and the US. They propose a roadmap for sharing strategies, standards, and data internationally to accelerate implementation.

Abstract

Genomic sequencing is rapidly transitioning into clinical practice, and implementation into healthcare systems has been supported by substantial government investment, totaling over US$4 billion, in at least 14 countries. These national genomic-medicine initiatives are driving transformative change under real-life conditions while simultaneously addressing barriers to implementation and gathering evidence for wider adoption. We review the diversity of approaches and current progress made by national genomic-medicine initiatives in the UK, France, Australia, and US and provide a roadmap for sharing strategies, standards, and data internationally to accelerate implementation. Genomic sequencing is rapidly transitioning into clinical practice, and implementation into healthcare systems has been supported by substantial government investment, totaling over US$4 billion, in at least 14 countries. These national genomic-medicine initiatives are driving transformative change under real-life conditions while simultaneously addressing barriers to implementation and gathering evidence for wider adoption. We review the diversity of approaches and current progress made by national genomic-medicine initiatives in the UK, France, Australia, and US and provide a roadmap for sharing strategies, standards, and data internationally to accelerate implementation.