Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome

Molecular characterization of a peripheral receptor for cannabinoids

Sean Munro, Kerrie L. Thomas, Muna Abu-Shaar · Nature · 1993 · 5K citations

Cannabis Use, Molecular Pharmacology, Functional Selectivity +7

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Auvro R. Mridha, Alexander Wree, Avril A. B. Robertson et al. · Journal of Hepatology · 2017 · 1K citations · Full text

Inflammation, Fibrosis, Liver Fibrosis +14

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

Soichi Sano, Kosei Oshima, Ying Wang et al. · Journal of the American College of Cardiology · 2018 · 646 citations · Full text

Inflammation, Cytokine, Heart Failure +11

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

Minako Ito, Takashi Shichita, Masahiro Okada et al. · Nature Communications · 2015 · 410 citations · Full text

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Gerardus P. J. van Hout, Lena Bosch, Guilielmus H.J.M. Ellenbroek et al. · European Heart Journal · 2016 · 317 citations · Full text