The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

Michela Palmieri, Soren Impey, Hyojin Kang et al. · Human Molecular Genetics · 2011 · 961 citations

Mitophagy, Cellular Clearance Pathways, Genetics +25

Phenotype, diagnosis, and treatment of Gaucher's disease

Gregory A. Grabowski · The Lancet · 2008 · 621 citations

Mendelian Disorder, Genetic Disorder, Pathology +3

Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

Jesper Nylandsted, Mads Gyrd‐Hansen, Agnieszka Danielewicz et al. · The Journal of Experimental Medicine · 2004 · 543 citations · Full text

Apoptosis, Immunology, Cell Death +18

LIMP-2 Is a Receptor for Lysosomal Mannose-6-Phosphate-Independent Targeting of β-Glucocerebrosidase

David Reczek, Michael Schwake, J Schröder et al. · Cell · 2007 · 518 citations · Full text

Protein Function, Signal Transduction, Biochemistry +8

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

Thomas Kirkegaard, Anke G. Roth, Nikolaj H.T. Petersen et al. · Nature · 2010 · 513 citations · Full text

Protein Function, Lysosomal Storage Disease, Autophagy +4