Ranolazine prevents pressure overload‐induced cardiac hypertrophy and heart failure by restoring aberrant Na⁺ and Ca²⁺ handling

Abstract

Our study demonstrates that inhibition of late sodium current with ranolazine improves pressure overload-induced cardiac hypertrophy and systolic and diastolic function by restoring Na⁺ and Ca ²⁺ handling, inhibiting the downstream hypertrophic pathways and ER stress. Inhibition of late sodium current may provide a new treatment strategy for cardiac hypertrophy and heart failure.