Concepedia

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

Monica Bodogai, Jennifer O’Connell, Ki H. Kim, Yoo Kim, Kanako Moritoh, Chen Chen, Fedor Gusev, Kelli L. Vaughan, Natalia Shulzhenko, Julie A. Mattison,

Science Translational Medicine · 2018 · 181 citations · 68 references

DOIFull text

Open access

Concepts

Abstract

monocytes or 4BL cells had the same effect on IR. These results underscore the pathological function of B1a cells and suggest that the microbiome-monocyte-B cell axis could potentially be targeted to reverse age-associated IR.

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