Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours

Signatures of mutational processes in human cancer

Nature · 2013 · 9.9K citations · Full text

Somatic Variant, Tumor Heterogeneity, Mutational Processes +6

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

Jason D. Buenrostro, Paul G. Giresi, Lisa C. Zaba et al. · Nature Methods · 2013 · 6.8K citations · Full text

Chromatin, Native Chromatin, Chromatin Remodeling +15

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber, Junwei Shi, Eric Wang et al. · Nature · 2011 · 1.9K citations

Hematological Malignancy, Hematology, Myeloid Neoplasia +7

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A. Dawson, Rab K. Prinjha, Antje Dittmann et al. · Nature · 2011 · 1.5K citations · Full text

Hematological Malignancy, Chromatin, Bet Recruitment +11

Deciphering Signatures of Mutational Processes Operative in Human Cancer

Ludmil B. Alexandrov, Serena Nik‐Zainal, David C. Wedge et al. · Cell Reports · 2013 · 1.3K citations · Full text