Hyperresponsiveness to interferon gamma exposure as a response mechanism to anti-PD-1 therapy in microsatellite instability colorectal cancer

The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints

Nicolás J. Llosa, Michael Cruise, Ada Tam et al. · Cancer Discovery · 2014 · 1.4K citations · Full text

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

Jianjun Gao, Lewis Z. Shi, Hao Zhao et al. · Cell · 2016 · 1.3K citations · Full text

Tumor Biology, Cancer Immunosurveillance, Medicine +10

EGFR mutation correlates with uninflamed phenotype and weak immunogenicity, causing impaired response to PD-1 blockade in non-small cell lung cancer

Zhong‐Yi Dong, Jia‐Tao Zhang, Si‐Yang Maggie Liu et al. · OncoImmunology · 2017 · 433 citations · Full text

<scp>PD</scp>‐L1 expression is mainly regulated by interferon gamma associated with <scp>JAK</scp>‐<scp>STAT</scp> pathway in gastric cancer

Kousaku Mimura, Jun Liang Teh, Hirokazu Okayama et al. · Cancer Science · 2017 · 314 citations · Full text

PD-L1 induced by IFN-γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer

Xiaohui Zhang, Yuanyuan Zeng, Qiu‐Xia Qu et al. · International Journal of Clinical Oncology · 2017 · 301 citations

Tumor-associated Macrophages, Cancer Immunosurveillance, Lung Inflammation +9