Concepedia

Vitamin E δ-tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides

Chao Yang, Qing Jiang

The Journal of Nutritional Biochemistry · 2018 · 43 citations · 34 references

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Concepts

References

34

NF-κB functions as a tumour promoter in inflammation-associated cancer

Eli Pikarsky, Rinnat M. Porat, Ilan Stein et al. · Nature · 2004 · 2.4K citations

, , +16

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Ingrid E. Wertz, Karen O’Rourke, Honglin Zhou et al. · Nature · 2004 · 1.8K citations

, , +12

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

Eric G. Lee, David L. Boone, Sophia Chai et al. · Science · 2000 · 1.4K citations · Full text

, , +17

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

David L. Boone, Emre E. Turer, Eric G. Lee et al. · Nature Immunology · 2004 · 1.1K citations

, , +14

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

Mara Compagno, Wei Keat Lim, Adina Grunn et al. · Nature · 2009 · 1K citations

, , +10