Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

Mara Compagno, Wei Keat Lim, Adina Grunn, +11

Nature

Lymphoid NeoplasiaMultiple GenesImmunologyPathologyCancer Genomics +5

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

Roberto Chiarle, Yu Zhang, Richard L. Frock, +12

Cell

ChromatinGenome InstabilityGeneticsB CellsChromosome Biology +6

AID is required for germinal center–derived lymphomagenesis

Laura Pasqualucci, Govind Bhagat, Mila Janković, +7

Nature Genetics

MedicineCell BiologyTumor BiologyLymphoid Neoplasia

Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma

Laura Pasqualucci, Mara Compagno, Jane Houldsworth, +7

The Journal of Experimental Medicine

The NF-κB negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas

Urban Novak, Andrea Rinaldi, Ivo Kwee, +12

Blood

Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

Mara Compagno, Qi Wang, Chiara Pighi, +17

Nature

Signal TransductionSignaling PathwayCell RegulationImmunologyB Cells +3

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

Federico Gulluni, Miriam Martini, Maria Chiara De Santis, +23

Cancer Cell

ChromatinChromatin StructureCell DivisionGenomic StabilityNatural Sciences +10

Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome

Marco Ladetto, Sonia Vallet, Andreas Trojan, +24

Blood

Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

Matteo Menotti, Chiara Ambrogio, Taek-Chin Cheong, +24

Nature Medicine

Lymphoid NeoplasiaWiskott–aldrich Syndrome ProteinImmunodeficienciesImmunologyPathology +6

Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

Taek-Chin Cheong, Mara Compagno, Roberto Chiarle

Nature Communications