PI3K/Akt/mTOR signaling pathway participates in Streptococcus uberis-induced inflammation in mammary epithelial cells in concert with the classical TLRs/NF-ĸB pathway

PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms

John Brognard, Emma Sierecki, Tianyan Gao et al. · Molecular Cell · 2007 · 573 citations · Full text

Molecular Physiology, Signal Transduction, Akt Signaling +14

PI3K-mediated negative feedback regulation of IL-12 production in DCs

Taro Fukao, M. Tanabe, Yasuo Terauchi et al. · Nature Immunology · 2002 · 522 citations

Inflammation, Cytokine, Signal Transduction +8

Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-κB in mammary epithelial cells and to quickly induce TNFα and interleukin-8 (CXCL8) expression in the udder

Wei Yang, Holm Zerbe, Wolfram Petzl et al. · Molecular Immunology · 2008 · 277 citations

Inflammation, Bovine Tlr2, Cytokine +14

Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system

Florence B. Gilbert, Patricia Cunha, Kirsty Jensen et al. · Veterinary Research · 2013 · 241 citations · Full text

Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury

Yue Hu, Jian Lou, Yuanyuan Mao et al. · Autophagy · 2016 · 197 citations · Full text

Acute Lung Injury, Mitophagy, Inflammatory Lung Disease +25