Concepedia

Hydroxyethyl substituted linear polyethylenimine for safe and efficient delivery of siRNA therapeutics

Sushilkumar Patil, Rohan Lalani, Priyanka Bhatt, Imran Vhora, Vivek Patel, Hinal Patel, Ambikanandan Misra

RSC Advances · 2018 · 32 citations · 32 references

DOIFull text

Open access

Concepts

Abstract

studies showed enhanced cell uptake and mRNA knockdown efficiency. Thus, the proposed modification shows a simple approach to overcome the limitation of LPEI for siRNA delivery.

References

32

In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis

Dagmar Fischer, Youxin Li, Barbara Ahlemeyer et al. · Biomaterials · 2003 · 2.3K citations

, , +16

A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy

S. Moein Moghimi, Peter Symonds, J. Clifford Murray et al. · Molecular Therapy · 2005 · 1.1K citations · Full text

, , +17

Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo

Lionel Wightman, Ralf Kircheis, Vanessa R�ssler et al. · The Journal of Gene Medicine · 2001 · 693 citations

, , +16

Dekker encyclopedia of nanoscience and nanotechnology

Choice Reviews Online · 2005 · 684 citations

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Development and characterisation of chitosan nanoparticles for siRNA delivery

Haliza Katas, H. Oya Alpar · Journal of Controlled Release · 2006 · 642 citations

, , +14