Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.3K citations

Inflammation, Mitochondrial Function, Cell Death +7

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.8K citations · Full text

Inflammation, Signal Transduction, Oxysterol +12

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

Charles L. Evavold, Jianbin Ruan, Yunhao Tan et al. · Immunity · 2017 · 1.1K citations · Full text

Inflammation, Cytokine, Inflammatory Lung Disease +11

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

Greta Guarda, Marion Braun, Francesco Staehli et al. · Immunity · 2011 · 911 citations · Full text

Inflammation, Cytokine, Inflammasome Activation +4

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

Frederick J. Sheedy, Alena Grebe, Katey J. Rayner et al. · Nature Immunology · 2013 · 878 citations · Full text

Inflammation, Particulate Ligands, Immunology +9