Frederick J. Sheedy

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel et al. · Cell Metabolism · 2015 · 1.4K citations · Full text

Life Sciences, Biochemistry, Immunology +16

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

Frederick J. Sheedy, Eva M. Pålsson‐McDermott, Elizabeth J. Hennessy et al. · Nature Immunology · 2009 · 1K citations

Life Sciences, Immunology, Molecular Biology +16

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

Frederick J. Sheedy, Alena Grebe, Katey J. Rayner et al. · Nature Immunology · 2013 · 906 citations · Full text

Life Sciences, Cell Biology, Immunology +13

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

Katey J. Rayner, Christine Esau, Farah Hussain et al. · Nature · 2011 · 697 citations · Full text

Life Sciences, Molecular Biology, Physiology +12

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

Katey J. Rayner, Frederick J. Sheedy, Christine Esau et al. · Journal of Clinical Investigation · 2011 · 684 citations

Life Sciences, Molecular Biology, Molecular Medicine +17