Antioxidative stress effects of vitamins C, E, and B<sub>12</sub>, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats

Abstract

Pretreatment with vitamins C, E, B₁₂, or their combination was found to be beneficial in preventing in vivo hepatic oxidative stress induced by APAP overdose. Vitamin C on its own showed superior protection against APAP-induced liver injury in rats compared to the other vitamins. The proliferation of APAP-intoxicated liver cells in vitro was highest when protected with the vitamins' combination.