Profile of cardiac lipid metabolism in STZ-induced diabetic mice

Wenjie Li, Min Yao, Ruonan Wang, Yun Shi, Lianguo Hou, Ziyuan Hou, Kaoqi Lian, Nan Zhang, Yaqi Wang, Weiwei Li,

Lipids in Health and Disease · 2018 · 42 citations · 27 references

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Abstract

Our data suggest that the increase in toxic lipid species and decreased in PUFAs undergoing peroxisomal β-oxidation, combined with the reduction in phospholipids cause mitochondrial injury and subsequent uncoupling of phosphorylation and ATP deficiency; thereby leading to diabetic heart dysfunction.

References

27