Concepedia

Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation

Tomoyuki Ohe, Ryutaro Umezawa, Yumina Kitagawara, Daisuke Yasuda, Kyôko Takahashi, Shigeo Nakamura, Akiko Abe, Shuichi Sekine, Kousei Ito, Kentaro Okunushi,

Bioorganic & Medicinal Chemistry Letters · 2018 · 13 citations · 13 references

DOI

Concepts

References

13

Ipso substitution of bisphenol A catalyzed by microsomal cytochrome P450 and enhancement of estrogenic activity

Shigeo Nakamura, Yoshito Tezuka, Atsuko Ushiyama et al. · Toxicology Letters · 2011 · 89 citations

, , +17

Hepatic injury caused by benzbromarone

Melanie M. van der Klauw, P. M. Houtman, Bruno H. Stricker et al. · Journal of Hepatology · 1994 · 81 citations

, , +12

Sequential Metabolism and Bioactivation of the Hepatotoxin Benzbromarone: Formation of Glutathione Adducts From a Catechol Intermediate

Matthew G. McDonald, Allan E. Rettie · Chemical Research in Toxicology · 2007 · 77 citations

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Novel Metabolic Pathway of Arylethers by Cytochrome P450: Cleavage of the Oxygen-Aromatic Ring Bond Accompanying ipso-Substitution by the Oxygen-Atom of the Active Species in Cytochrome P450 Models and Cytochrome P450

Tomoyuki Ohe, T. Mashino, Masaaki Hirobe · Archives of Biochemistry and Biophysics · 1994 · 62 citations

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Substituent elimination from p-substituted phenols by cytochrome P450. ipso-Substitution by the oxygen atom of the active species.

Tomoyuki Ohe, Tadahiko Mashino, Masaaki Hirobe · PubMed · 1997 · 60 citations

, , +16