Transition metal free decarboxylative fluoroalkylation of <i>N</i>-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)

Abstract

A novel transition metal-free decarboxylative fluoroalkylation of activated alkenes and C-H functionalization cascade process has been developed. This approach provides an efficient way to construct valuable 1,1-dimethyl-2,2,2-trifluoroethyl substituted oxindoles.