Concepedia

Pathologic Fibroblasts in Idiopathic Subglottic Stenosis Amplify Local Inflammatory Signals

R. J. Morrison, Nicolas‐George Katsantonis, Kevin Motz, Alexander T. Hillel, C. Gaelyn Garrett, James L. Netterville, Christopher T. Wootten, Susan M. Majka, Timothy S. Blackwell, Wonder P. Drake,

Otolaryngology · 2018 · 58 citations · 38 references

DOIFull text

Open access

Abstract

IL-17A directly drives iSGS scar fibroblast proliferation, synergizes with transforming growth factor ß1 to promote extracellular matrix production, and amplifies local inflammatory signaling. Glucocorticoids appear to partially abrogate fibroblast-dependent inflammatory signaling. These results offer mechanistic support for future translational study of clinical reagents for manipulation of the IL-17A pathway in iSGS patients.

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