Concepedia

A road map for prioritizing warheads for cysteine targeting covalent inhibitors

Péter Ábrányi‐Balogh, László Petri, Péter A. Szijj, Andrea Scarpino, Martina Hrast, Ana Mitrović, Urša Pečar Fonović, Krisztina Németh, Hélène Barreteau, David I. Roper,

European Journal of Medicinal Chemistry · 2018 · 126 citations · 32 references

DOI

Concepts

References

32

Quantitative reactivity profiling predicts functional cysteines in proteomes

Eranthie Weerapana, Chu Wang, Gabriel M. Simon et al. · Nature · 2010 · 1.7K citations · Full text

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The Thiol-Michael Addition Click Reaction: A Powerful and Widely Used Tool in Materials Chemistry

Devatha P. Nair, Maciej Podgórski, Shunsuke Chatani et al. · Chemistry of Materials · 2013 · 1.6K citations

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Proteome-wide covalent ligand discovery in native biological systems

Keriann M. Backus, Bruno E. Correia, Kenneth M. Lum et al. · Nature · 2016 · 978 citations

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The refined 2.15 A X‐ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

Djordje Müsil, Damir Zucić, Richard A. Engh et al. · The EMBO Journal · 1991 · 602 citations · Full text

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Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

Iana M. Serafimova, Miles A. Pufall, Shyam Krishnan et al. · Nature Chemical Biology · 2012 · 500 citations

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