Proteome-wide covalent ligand discovery in native biological systems

Keriann M. Backus, Bruno E. Correia, Kenneth M. Lum, +9

Nature

BiochemistryNatural SciencesProteomicsNative Biological SystemsMolecular Recognition +1

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

Ekaterina V. Vinogradova, Xiaoyu Zhang, David Remillard, +25

Cell

Electrophile-cysteine InteractionsSignal TransductionBiochemistryCell InteractionCell Trafficking +8

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells

Micah J. Niphakis, Kenneth M. Lum, Armand B. Cognetta, +8

Cell

Proteinlipid InteractionSignal TransductionTheir LigandabilityLipid RaftsBiochemistry +10

Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric with Endocannabinoid Substrates

Jae Won Chang, Micah J. Niphakis, Kenneth M. Lum, +7

Chemistry & Biology

Chemical BiologyEndocannabinoid SubstratesLipid SynthesisBiochemistryNatural Sciences +6

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

Jarrett R. Remsberg, Radu M. Suciu, Noemi A. Zambetti, +15

Nature Chemical Biology

Cell SignalingMedicinePathologyCell ProliferationTumor Suppressor +7

Chemical Proteomic Profiling of Human Methyltransferases

Benjamin D. Horning, Radu M. Suciu, Darian A. Ghadiri, +7

Journal of the American Chemical Society

Epigenetic ChangeMolecular BiologyNative Biological SystemsMethyl GroupsChemical Biology +21

Detection of inapparent nodule-transformed cells in the mammary gland tissues of virgin female BALB/cfC3H mice.

K. B. DeOme, M J Miyamoto, Rebecca C. Osborn, +2

Munich Personal RePEc Archive (Ludwig Maximilian University of Munich)

Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator

Doğukan Mizrak, N. Sumru Bayın, Jinzhou Yuan, +8

Cell Reports

Cardiac Progenitor CellsCellular NeurobiologyLineage Progression DynamicsSingle Cell SequencingNew Olfactory Bulb +15

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

Alice P. Chen, Kenneth M. Lum, Pablo Lara-González, +9

Nature Chemical Biology

Lifespan ExtensionSignal TransductionSignaling PathwayPharmacological Convergence RevealsLongevity +5

Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors

Balyn W. Zaro, Landon R. Whitby, Kenneth M. Lum, +1

Journal of the American Chemical Society

Drug TargetTyrosine KinasePharmacotherapyChemical BiologyCovalent Kinase Inhibitors +16