A road map for prioritizing warheads for cysteine targeting covalent inhibitors

Péter Ábrányi‐Balogh, László Petri, Péter A. Szijj, +13

European Journal of Medicinal Chemistry

Molecular DockingMedicinal ChemistryCovalent InhibitorsDrug TargetBiochemistry +8

Synthesis and structure–activity relationship study of novel quinazolinone-based inhibitors of MurA

Martina Hrast, Kaja Rožman, Marko Jukič, +3

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryStructure–activity Relationship StudyMedicineNatural Sciences +9

Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds

Anja Kolarič, Thomas Germe, Martina Hrast, +7

Nature Communications

Structure–activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF

Martina Hrast, Samo Turk, Izidor Sosič, +9

European Journal of Medicinal Chemistry

BiosynthesisBiochemistryNatural SciencesBiocatalysisMedicine +6

Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF

Matej Sova, Andreja Kovač, Samo Turk, +3

Bioorganic Chemistry

BiosynthesisEngineeringBacteriologyBiotechnologyNatural Product Biosynthesis +5

Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC–MurF)

Andrej Perdih, Martina Hrast, Hélène Barreteau, +3

Bioorganic & Medicinal Chemistry

DerivativesAntibioticsMedicineMultiple InhibitorsAntibacterial Agent +8

Ellipticines and 9-acridinylamines as inhibitors of d-alanine:d-alanine ligase

Blaž Vehar, Martina Hrast, Andreja Kovač, +6

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicine +7

Heterocyclic electrophiles as new MurA inhibitors

Aaron Keeley, Péter Ábrányi‐Balogh, Martina Hrast, +3

Archiv der Pharmazie

Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold

Martina Hrast, Marko Anderluh, Damijan Knez, +5

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryCyanothiophene ScaffoldMedicineNatural Sciences +5

Benzodioxane‐Benzamides as Antibacterial Agents: Computational and SAR Studies to Evaluate the Influence of the 7‐Substitution in FtsZ Interaction

Valentina Straniero, Víctor Sebastián-Pérez, Martina Hrast, +7

ChemMedChem