Antimicrobial Agents and Chemotherapy · 2018 · 40 citations · 64 references
Life SciencesMicrobiologyMolecular BiologyDrug DiscoveryGenomicsAntibiotic ResistanceAntibiotic Resistance MechanismsChemogenomic ProfilingDrug-target Interaction MappingAntibiotic DiscoveryAntibiotic Target AlterationCompetitive Fitness AssaysEssential Gene FunctionEssential Gene IdentificationHigh-throughput Screening AssaysNovel Antibacterial Drug DiscoverySearch For Multiple Targets
To streamline the elucidation of antibacterial compounds’ mechanism of action, comprehensive high-throughput assays interrogating multiple putative targets are necessary. However, current chemogenomic approaches for antibiotic target identification have not fully utilized the multiplexing potential of next-generation sequencing.
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