Concepedia

Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness

Rizwan Qaisar, Shylesh Bhaskaran, Rojina Ranjit, Kavithalakshmi Sataranatarajan, Pavithra Premkumar, Kendra Huseman, Holly Van Remmen

Redox Biology · 2018 · 93 citations · 29 references

DOIFull text

Open access

Concepts

Abstract

mice. Taken together our findings suggest that the pharmacological restoration of SERCA is a promising therapeutic approach to counter oxidative stress-associated muscle impairment.

References

29

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

Sailaja Elchuri, Terry D. Oberley, Wenbo Qi et al. · Oncogene · 2004 · 665 citations

, , +14

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

Florian L. Müller, Wook Song, Yuhong Liu et al. · Free Radical Biology and Medicine · 2006 · 445 citations

, , +15

Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

David Sebastián, Eleonora Sorianello, Jessica Segalés et al. · The EMBO Journal · 2016 · 389 citations

, , +16

Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production

Florian L. Müller, Wook Song, Youngmok C. Jang et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2007 · 356 citations

, , +17

Increased superoxide <i>in vivo</i> accelerates age‐associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

Youngmok C. Jang, Michael S. Lustgarten, Yuhong Liu et al. · The FASEB Journal · 2009 · 293 citations · Full text

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