A designer bow-tie combination therapeutic platform: An approach to resistant cancer treatment by simultaneous delivery of cytotoxic and anti-inflammatory agents and radiation

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DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

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Life Sciences, Genetics, Molecular Biology +17

Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

Ian Hickson, Yan Zhao, Caroline J. Richardson et al. · Cancer Research · 2004 · 1.2K citations

Life Sciences, Molecular Biology, Oncology +16

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

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Medicine, Genetics, Oncology +13

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles

Shanta Dhar, Frank Gu, Róbert Langer et al. · Proceedings of the National Academy of Sciences · 2008 · 990 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +14