Concepedia

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1

Mei‐Hong Lu, Wen‐Li Ji, De-En Xu, Pei-Pei Yao, Xiu‐Yun Zhao, Zhaotao Wang, Li‐Pao Fang, Rui Huang, Li-Jun Lan, Ji-Bo Chen,

Experimental Neurology · 2018 · 23 citations · 44 references

DOI

Concepts

References

44

Protein kinase C and lipid signaling for sustained cellular responses

Yasutomi Nishizuka · The FASEB Journal · 1995 · 2.5K citations

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Thorlákur Jónsson, Jasvinder K. Atwal, Stacy Steinberg et al. · Nature · 2012 · 1.7K citations

, , +16

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David Borchelt, Gopal Thinakaran, Christopher B. Eckman et al. · Neuron · 1996 · 1.5K citations · Full text

, , +17

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1.1K citations

, , +14

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

Tilman Schneider‐Poetsch, Jianhua Ju, Daniel E. Eyler et al. · Nature Chemical Biology · 2010 · 1K citations · Full text

, , +11