Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK

Long‐term follow‐up of patients with NAFLD and elevated liver enzymes†‡

Mattias Ekstedt, Lennart Franzén, Ulrik Mathiesen et al. · Hepatology · 2006 · 2.3K citations

Medicine, Pathology, Clinical Epidemiology +16

Induction of autophagy by spermidine promotes longevity

Tobias Eisenberg, Heide Knauer, Alexandra Schauer et al. · Nature Cell Biology · 2009 · 1.7K citations · Full text

Life Sciences, Biology, Cell Biology +11

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Simon A. Hawley, Matt Davison, Angela Woods et al. · Journal of Biological Chemistry · 1996 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Nonalcoholic Fatty Liver Disease (NAFLD) Activity Score and the Histopathologic Diagnosis in NAFLD: Distinct Clinicopathologic Meanings §Δ

Elizabeth M. Brunt, David E. Kleiner, Laura Wilson et al. · Hepatology · 2010 · 1.2K citations · Full text

Medicine, Pathology, Gastroenterology +16

Cardioprotection and lifespan extension by the natural polyamine spermidine

Tobias Eisenberg, Mahmoud Abdellatif, Sabrina Schroeder et al. · Nature Medicine · 2016 · 1.1K citations · Full text

Education, Pharmacology, Physiology +6