Proceedings of the National Academy of Sciences · 2018 · 60 citations · 39 references
Life SciencesCell BiologyMolecular BiologyCell SignalingCytoskeletonSignal TransductionCell MigrationCell Signaling NetworksRas Family OncogenesSignal Transduction In CancerSignal Transduction PathwaysSignaling NetworksCancer Metastasis MechanismsCell Migration DynamicsExcitable SystemsPi3k SignalingPositive Feedback LoopsRas Signaling PathwaySignal Transduction DynamicsSignaling Pathway Dynamics
Significance Cell migration is central in physiological and pathological conditions such as immune response and cancer metastasis. The excitable network hypothesis can account for recent observations of propagating waves of signal transduction and cytoskeleton events as well as behaviors of migrating cells. However, the molecular feedback loops involved in these networks that bring about excitability are poorly understood. Here, we provide evidence for a positive-feedback loop based on a mutual inhibitory interaction between Ras and phosphatidylinositol (3,4)-bisphosphate [PI(3,4)P 2 ]. Our results uncover an important role of PI(3,4)P 2 in the regulation of Ras activity, which may extend well beyond cell migration.
39
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate
York Posor, Marielle Eichhorn-Gruenig, Dmytro Puchkov et al. · Nature · 2013 · 404 citations