Concepedia

Analysis of Interactions between Telomeric i‐Motif DNA and a Cyclic Tetraoxazole Compound

Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrien Marchand, Fernaldo Richtia Winnerdy, Valérie Gabelica, Anh Tuân Phan, Masato Katahira, Kazuo Nagasawa

ChemBioChem · 2018 · 21 citations · 19 references

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Abstract

The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that 1 interacts with the i-motif structure at two preferred binding sites.

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