New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity

Abstract

Five new chromone derivatives, arthones A⁻E (<b>1</b>⁻<b>5</b>), together with eight known biogenetically related cometabolites (<b>6</b>⁻<b>13</b>), were isolated from a deep-sea-derived fungus <i>Arthrinium</i> sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of <b>1</b> and <b>5</b> were established by electronic circular dichroism (ECD) calculations and that of <b>2</b> was determined by modified Mosher ester method. Compounds <b>3</b> and <b>8</b> exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC₅₀ values ranging from 16.9 to 18.7 μM. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 μM.